Treatment of gout with drugs that remove uric acid. The use of blemaren in the treatment of patients with gout. Who is the drug indicated for?

A person often learns about the presence of urolithiasis suddenly: a painful attack begins abruptly, which can sometimes even give a painful shock.

On examination, it turns out that the person has a kidney stone.

In this case, surgery is the last thing you can think about. Pharmacology does not stand still and now there are drugs that help to really dissolve some stones. Especially if they are in the form of sand and remove them from the body.

Blemarin.

This is one of these drugs, but it does not work on all types of stones.

The salts that accumulate in the urine can be completely different. To find out the type of stones in a particular person, you can focus on a urine test - the type of salts will be indicated there.

If the salts in the urine are acidic, oxalate-calcic and some are mixed, then you can try using Blemaren.

Contraindications.

Renal failure, both acute and chronic.

Urinary tract infections.

After determining the pH of urine, if the value is above 7.

If a strict salt-free diet is prescribed.

With increased sensitivity to the components of the drug.

Indications.

The drug prevents the formation of calcium and oxalate stones, dissolves uric acid stones. It can be used to alkalize urine if necessary: for example, the patient is being treated with drugs that can increase the excretion of uric acid.

Dosage.

Effervescent tablets, before use they must be dissolved in 200 ml of liquid. Tea and fruit juices are allowed, but it is usually better to do this in plain water.

From 2 to 6 tablets are prescribed per day - the doctor specifically decides, based on the patient's condition and the results of the examination. The daily dose should be distributed evenly throughout the day. The drug is taken after meals. P duration of treatment is long. up to half a year.

Some time after the start of treatment, a control urine test determines whether the dose is correctly selected, this is indicated by the pH of the urine. It must be in certain numbers during the day. If the pH of the urine is below the indicated figures, then the dose of the drug is increased, if it is higher, then it is slightly reduced.

Determining the pH of urine at home.

Determination of pH of urine is carried out three times a day. Since this is not always possible in a hospital setting and the patient is treated on an outpatient basis, you need to purchase indicator paper and use the color on this paper to determine the actual pH value.

Side effects.

The drug is easily tolerated, side effects are not indicated. There have been isolated cases of allergic reactions or edema, as well as nutritional problems, as with any drug.

An overdose of Blemaren is not possible.

Effervescent tablets contain potassium and sodium. That is why patients who cannot use table salt should not be prescribed this drug.

When taking blemaren, you should adhere to a certain diet: you need to limit foods with a predominant content of proteins and purines. You also need to drink plenty of water.

During pregnancy and lactation, the drug is not prescribed.

If the type of stones correspond to what the blemaren is supposed to fight against, the stone decreases in size after a while and can come out on its own. This is a high quality and effective product.

Clarification: Blemaren can affect tooth enamel, so it is advisable to drink the effervescent solution through a straw.

Important note: after opening the package, you need to protect the tablets from moisture. Therefore, they cannot be stored in the kitchen and in the bathroom.

Before use, be sure to consult a specialist

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Gout is a disease characterized by excessive accumulation of uric acid in the body. There are many ways to treat this pathology. Complex therapy includes many types of exposure. The main of these types of treatment for gout is the use of medications that remove uric acid. Consider the most common and effective means used for this purpose.

Types of medicines for the removal of uric acid salts

In order to reduce the levels of this acid in the body, the following groups of drugs are used:

Uricodepressive agents. They help to reduce the amount of this component in the body by removing urates from the articular tissues.
uricosuric agents. They are aimed at reducing the reabsorption of urate in the tubules of the kidneys.
Mixed drugs. Their action is to reduce the release of acid with a more active excretion of it from the body along with urine.

Thanks to these drugs, salts are more actively removed from the joints, thereby helping to alleviate the patient's condition with gout.

Important to remember! Treatment of gout with drugs that remove acid should be prescribed only by the attending physician!

Overview of uricodepressive drugs

These drugs are prescribed in such cases:

gout with the formation of tophi;
joint damage, accompanied by diseases of the circulatory system;
kidney disease associated with high excretion of uric acid salts;
the presence of stones in the bladder.

Let us consider in more detail the most common drugs of the uriodepressive group.

This drug is available in the form of tablets. It helps to reduce the concentration of salts, thereby reducing their level in the body. Allopurinol should be taken 3-4 times a day immediately after eating. The duration of treatment and the number of tablets is determined by the severity of the disease. The drug is contraindicated in such situations:

during pregnancy and lactation;
a severe form of diseases associated with impaired functioning of the endocrine system;
disruption of the kidneys.

Allopurinol has a beneficial effect on the synthesis of uric acid.

Febuxostat

This drug is for long-term use. According to the results of the tests, you can notice a decrease in the amount of uric acid after 2-3 months. Febuxostat is processed through the liver, which significantly reduces the load on the kidneys. Therefore, it can be used in the treatment of gout in a person with renal insufficiency. The only drawback of the drug is its high cost.

Orotic acid

This medication comes in the form of granules or tablets. It takes no more than 20 days to take Orotic acid, after which you should take a break. Enhances the excretion of uric acid. But, compared with analogues, Orotic acid is a less potent drug. Therefore, it is used in the early stages of gout development.

Pegloticase

This is a drug that is made on the basis of beef liver. Available in the form of a solution for injection. It is less active when compared with analogues, but has virtually no side effects. It is required to inject the solution intramuscularly 3 times a week.

Overview of uricosuric drugs

Uricosuric agents also help to reduce the level of salts in gout. Consider the most effective drugs in this group.

probenecid

This tool is aimed at the absorption of acid crystals by the tubules of the kidneys, followed by its removal from the body. Despite its high efficiency, Probenecid has one significant drawback: it only removes salt crystals, but does not suppress their accumulation in the blood. Therefore, this drug is not suitable for the treatment of gout during an exacerbation.

Sulfinpyrazone

This drug should be taken after eating food. It contributes to the active excretion of salts in gouty arthritis. The disadvantage of Sulfinpyrazone is a significant number of contraindications. The medicine should not be taken in such cases:

stomach or duodenal ulcer;
severe kidney disease;
dysfunction of the liver.

The use of Sulfinpyrazone negatively affects the patient's condition from the gastrointestinal tract.

Atofan

This medication is actively used during an exacerbation of gout. Since it weakly removes acid from the articular tissues. The medicine negatively affects the work of the gastrointestinal tract, liver and kidneys. Therefore, it is recommended to use it only during periods of exacerbation.

The composition of this drug includes only natural ingredients. Its action is aimed at blocking uric acid crystals from settling in the articular tissues. Colchicine is used only during periods of exacerbations of gout, since in steel time it can cause a large number of side effects.

Mixed medicines

The use of drugs in this group contributes to the active removal of acid salts, but at the same time reduces the occurrence of side effects which reduces the risk of kidney or bladder stones.

Allomaron

This drug is used at any stage of the development of the disease. The medication is intended for long-term use. Some patients are prescribed Allomaron for 6 months. After this time, the patient has a significant improvement in his condition.

The drug contributes to the normalization metabolic processes, as a result of which stones in the kidneys or bladder can dissolve. Blemaren is used for a long period of time - at least 6 months. The main advantage of this medicine is the absence of side effects. Therefore, it is possible to treat gout during pregnancy and during breastfeeding. Blemaren is produced in the form of effervescent tablets, which should be dissolved in 1 glass of any liquid, except for alcoholic beverages.

Ketazon

This drug not only helps to remove uric acid salts along with purines, but also has an anti-inflammatory effect. Therefore, Ketazon is best used during periods of exacerbation of gouty arthritis. These tablets should be taken no longer than 3 weeks.

Long-term use of drugs aimed at lowering the level of uric acid helps to normalize this indicator, thereby significantly improving the patient's well-being. Also, these drugs reduce the risk of exacerbations. But the choice of the required remedy should be made only by the attending physician, taking into account the patient's condition and the severity of the disease.

To enhance the effectiveness of medications for gout, the patient must follow a special antipurine diet. This diet improves well-being, and also prevents the occurrence of exacerbations.

Blemaren is a drug used for urolithiasis both for the purpose of prevention and as a treatment. This combined preparation, belonging to the so-called citrate mixtures, includes sodium citrate, potassium bicarbonate and citric acid.

The selected concentrations of these substances, each of which is also sold separately, contribute to the dissolution of stones with a minimum of side effects. It belongs to the pharmacological group of combined agents that prevent the formation and promote the dissolution of stones. Blemaren is not an antibiotic, it is dispensed without a prescription - there are many reviews about this drug on the Internet.

pH of urine for urolithiasis and Blemaren

The effect of Blemaren is based on the effect on the acid-base balance of urine and the possibility of self-control, so the attached materials are not inferior in importance to the tablets themselves.

The pH level can indicate: an acidic environment (below 5.5), a neutral environment (5–7), an alkaline environment (above 7). Depending on the environment, certain stones are formed, and vice versa - depending on the change in the environment, the stones undergo dissolution.

Blemaren includes substances that change the pH towards alkalization relative to the current acidic state, which leads to the dissolution reaction of stones formed in an acidic environment.

To whom is the drug indicated?

Blemaren is indicated for use in the following conditions:

It should be borne in mind that Blemaren helps only with uric acid and calcium oxalate types of stones and is not prescribed for phosphate stones.

Medicines of this type are considered the safest.

Consider below how specialists and patients respond to the medication.

Opinion on the use of the drug by doctors and patients

In various forums, you can read the points of view of specialists and reviews of patients who took Blemaren:

The doctor I went to prescribed Allopurinol for a long time and stubbornly, but it didn’t help much. I stumbled upon Blémarin myself and bought it myself. Of the minuses, it is expensive, but they turn into pluses, because test strips for determining the acidity of urine are included in the price. According to the analysis of the level of uric acid before and after the intake, there was a change almost to the norm (it was 100 units above the upper limit of the norm).

The instructions say that it does not help with all types of stones - I did not know my type, but the doctor prescribed and in a month the stone decreased and left. Of the minuses - you need to monitor the acidity of urine when taking Blemaren and, in my opinion, the acidity of the oral cavity. I found a way out - to drink through a straw from the juice.

Andrei

A two-month course of Belarmen got rid of an oxalate stone of 4 millimeters, took 3 tablets a day, did not even use auxiliary measurements of acidity.

Sergey

The price is high, but the packaging is large and there are many additions - convenient tubes, a diary-calendar, indicators. I like these things, the treatment is interesting and following the recommendations is easy when you can do a self-examination yourself and see the result. Therefore, the price is justified (I found the cheapest option - a little more than a thousand), despite the simple composition. Simple but effective! After a month of admission, she was diagnosed: everything that was more than 3 mm was not found on ultrasound.

Marina

I Blemaren dissolved urate stones, was prescribed by a doctor. The pains were when the flakes came out - but I think they would be much more when the stones would come out as they were. I drink it in courses prophylactically, since the body is prone to the formation of stones on a constant basis.

Daniel

After the course of Blemaren, not only the urates resolved, but it also became easier with the joints.

Sofia

The husband drank 3 tablets a day, as prescribed by the doctor, there were two courses. So it didn't help. It's also a shame because it's so expensive.

Valentine

Didn't help with the stone. But she paid more than a thousand rubles for stomach problems. The composition is strange, there is almost nothing but acid - why such money?

Katia

The scheme is too complicated, you need to keep a diary, even from the minimum dose (less than 1/4 tablet), my acidity came out increased. The strips must be cut into four parts, otherwise they will not be enough. And with the stone did not help in the end.

Alexander

My story with Blémarin continued throughout my youth, the stone became larger, then smaller, reached one and a half centimeters, but did not dissolve. For about 10 years she took courses for six months, the stone is oxalate. Too expensive for a useless drug.

Lena

Blemaren drank, and from the urate stones he helped. But apparently because I didn’t really follow the pH, some others were formed, much more. As far as I understand, it is necessary to adhere very strictly to these boundaries, which are indicated. Because with a decrease, an environment is obtained in which stones of one type are formed, but when it is exceeded, it is also an environment for stone formation, only of a different type. If it is not possible to monitor the indicators, then it is worth weighing whether to drink it at all or not to drink it.

Natalia

How to take the drug correctly: instructions for use

The medicine is accompanied by a diary-calendar for keeping records and indicator paper. Depending on the acidity indicators, the patient himself regulates the amount of medication taken.

The task of using the product is to maintain the level of acidity of urine in the range of 6.6-6.8 pH. If you manage to keep these limits, then the selected dosage reaches the maximum effect. If the readings are higher, the dose should be reduced.

The measurement is made before the next dose of the drug, the color of the indicator is compared with the scale for 2 minutes.

Usually the average dose of medication is a dose of 3 tablets per day (may be up to 6).

Blemaren is available in a single dosage and form: "effervescent" capsules, which should be dissolved in a liquid before use, including fruit juices, tea, mineral water (alkaline). The medicine should be taken after meals.

In reviews of Blemaren, it is recommended to use a tube to avoid pH changes in the oral cavity. In addition, those who have undergone treatment are advised to cut the strips if necessary, otherwise their number may not be enough for the entire course of administration.

Children under 12 years of age are a contraindication for taking the drug due to the small number of clinical studies on the effects on the body and possible side effects at this age. Blemaren can potentially be prescribed by a doctor if a child has urolithiasis, if appropriate medical monitoring of the child's health is carried out.

Special instructions: diet and drinking regimen

When taking Blemaren, it is necessary to follow a diet with a low content of protein products (refusal of meat, fish), as well as a drinking regimen with plenty of fluids (due to the release of stones).

The tablet can be dissolved in mineral water, and, according to reviews, this avoids stomach pain. However, it should be borne in mind that not all mineral water has the desired composition.

When taking Blemaren, you can drink alkaline water:

Do not drink mineral water that lowers the pH of urine:

What is important to remember before taking the medication: contraindications and side effects

According to statistics, Blemaren rarely gives side effects due to the simplicity of the composition and the possibility of constant self-monitoring of the action of the drug.

The main side effects that may occur when taking the drug:

Please note that it is absolutely essential to follow the pH control using the supplied indicator paper. Failure to follow the rules of self-control will lead to the ineffectiveness of the drug or the formation of stones if the acid-base environment of the urine, as a result of taking it, goes beyond the recommended limits both in one direction and in the other.

Contraindications to the use of the drug are:

metabolic alkalosis;
renal failure in the acute stage;
heart failure;
established infection with microorganisms that break down urea;
urine pH above 7;
strict salt-free diet for severe arterial hypertension.

Estimated price in rubles

Prices for Blemaren in pharmacies vary from 1150 to 1300 rubles for 80 tablets (the only form of release).

Preparations for removing uric acid from the body with gout

Gout is one of the most common joint diseases, the cause of which is an excess of urates in the blood - salts of uric acid released during the breakdown of purines, which are elements of protein tissues. Crystallizing on the surface of the joints, urates injure them, causing severe pain when moving.

To reduce the level of uric acid, drugs of three types of action are used: uricodepressive - reducing the production of uric acid, uricosuric - increasing its excretion from the body, and mixed. Among the agents that inhibit the synthesis of urates is vitamin B13, or orotic acid for gout, it is included in the complex pharmaceutical therapy of the disease.

Principles of prescribing drugs

When a rheumatologist diagnoses a person with gout or gout, the next step is to determine the type of disease. Depending on the factors that led to the imbalance of purine metabolism, gout is divided into three types:

Metabolic - caused by a metabolic disorder;
Renal - in this case, the cause is a decrease in their normal function;
Mixed when both of these factors are present.

Lowering the level of urate in the blood can be achieved in two ways - by reducing the amount of uric acid produced by the body or by increasing its excretion - excretion from the body. With increased secretion of urates, genetically determined, primary gout is diagnosed. If the excess of the normal level of uric acid is associated with a reduced degree of functioning of the internal organs - most often the kidneys, then gout is called secondary.

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Gout often develops when both of these factors overlap. After determining what caused the excessive accumulation of urate in the blood - their hypersecretion or hypoexcretion, the doctor determines which drugs to reduce uric acid should be prescribed to the patient for treatment.

If a biochemical blood test shows an elevated level of uric acid (hyperuricemia), but no external symptoms of gout are observed, such drugs are not prescribed. They are prescribed only with frequent repetition of attacks of gouty arthritis, as well as in the presence of signs confirming its chronic form - tophi. This is the name of painless subcutaneous seals near the joints affected by gout, containing a mushy mass of yellowish-white color, which is a crystallized urate.

During an exacerbation of the disease, drugs to remove uric acid from the body with gout are not taken. First, you should reduce the severity of pain and inflammatory symptoms by taking non-steroidal anti-inflammatory drugs - NSAIDs.

Uricodepressive agents

The action of uricodepressants leads to a decrease in the synthesis of uric acid in the body. Allopurinol is one of the most popular drugs of this type. Its intake inhibits (reduces the activity) of the enzyme xanthine oxidase, under the influence of which hypoxanthine is converted to xanthine, and then to uric acid. The drug is available in the form of tablets of 100 mg (50 pieces in one package) and 300 mg (30 pieces in one package).

The price of the drug is from 70 to 100 rubles per package, depending on the number of tablets in it. White tablets have a round or oval shape, divided in half by a risk. One pill, in addition to the main active ingredient, contains a number of auxiliary ones that contribute to its better absorption:

Microcrystalline cellulose;
food gelatin;
Silica.

The dose in the treatment of gout is determined by the doctor. For an adult, the daily volume is from 100 to 900 mg, depending on the stage of development of the disease. The medicine is taken 2-4 times a day, after meals. The duration of the course of treatment depends on the severity of the course of the disease.

Among the side effects of treatment with Allolpurinol are noted:

Increased blood pressure;
Bradycardia - slow heart rate;
dizziness, headache;
Lethargy, drowsiness;
Violation of taste sensations.

At the beginning of the use of Allopurinol, due to the increased breakdown of urates crystallized on the surface of the joints, an increase in gouty attacks is possible. Contraindications to its use are pregnancy, breast-feeding, renal and hepatic insufficiency, individual intolerance to the substances that make up the drug, and children's age.

Thiopurinol is another uricodepressant. It is an analogue of Allopurinol, having a similar effect and similar rules of administration, but is better tolerated by patients. The price of the drug in the pharmacy chain is from 80 rubles.

Orotic acid, or vitamin B13. is a white powdery substance, which is a product of wine production. B13 helps to reduce the level of urates in the blood by binding uric acid salts. The vitamin has a dual effect - it combines the qualities of a urodepressant and uricozurite, which improves the excretion of urates from the body. Taken 1 teaspoon three times a day before meals. The course of gout treatment lasts 20 days, and after a three-week break it is repeated. The effectiveness of orotic acid in the treatment of gout is much lower than that of Allopurinol and Thiopurinol, but the number of its contraindications is also much less - individual intolerance and an allergic reaction. Therefore, vitamin B13 is often prescribed when other uricodepressants cannot be used. Thanks to this, as well as the low price (from 69 rubles), it is popular.

All of these drugs have a gradual effect, so they must be used for a long time. The total duration of the course of treatment is determined by the attending physician individually, depending on the patient's condition and the body's response to the use of drugs, and can take from several weeks to several months. During their adoption, it is necessary to periodically take tests to monitor the level of uric acid.

Uricosuric drugs

Also, experts recommend the treatment of gout with drugs that remove uric acid. This group of drugs includes drugs that have the ability to reduce the formation and deposition of urates on the articular surfaces by removing uric acid through the kidneys. Among the tablets for removing uric acid for gout include:

Fullflex - available in the form of oral (intended for swallowing) capsules and ointments for external use. The active substances of Fullflex are the extract of fragrant martinique root and white willow bark. The first of these components helps to remove excess fluid from the body along with uric acid salts, and the second - to relieve pain and inflammation. Fullflex is a dietary supplement (BAA), and due to its natural composition, it has practically no contraindications. The exception is pregnancy and lactation, as well as the age of up to 14 years, since there is no data on the use of the drug for the treatment of these categories of patients. The price of Fullflex capsules is from 300 to 350 rubles per pack of 30 pieces, a tube of ointment (75 g) costs 150 rubles. Capsules are taken 3-4 times a day, one at a time, half an hour after meals. They should be swallowed whole, without chewing, and washed down with boiled water. The ointment is applied in a thin layer on the diseased joint in the morning, before getting out of bed, and rubbed until completely absorbed. The course of treatment with one and the other type of drug for gout is one month;
Benemide is a drug for removing uric acid from the body, recommended for admission with short interruptions throughout the patient's life. Tests have proven that the main active ingredient of the tablets (probenecid) is one of the most effective means to remove uric acid. The price of the drug is quite high - 2850 rubles. It is very important to observe the daily dosage of the medicine. You need to start treatment with a dose of ½ tablet 2 times a day, gradually reaching one pill per day. A month later, screening tests are taken, and if necessary, the doctor makes an adjustment in the direction of increasing the dose. The maximum dosage is 4 tablets per day;
Flexen is available in the form of gelatin capsules, suppositories, gel for external use and solution for injection. The active substance of all four forms of the drug is Ketoprofen, which belongs to the group of NVPS - non-steroidal anti-inflammatory drugs. The price of candles is from 180 to 220 rubles, capsules - from 150 to 190 rubles (depending on their number in the package), the gel costs 150-195 rubles, the injection solution - 190-230 rubles. The dosage of capsules taken after meals is from 2 to 6 per day, suppositories - 1-2 per day. The ointment is rubbed into the skin in the morning and at night, as well as intramuscular injections. The course of treatment is prescribed individually in each individual case;

Blemaren has the effect of alkalization of urine, due to which its acidity falls, and the level of urates in it decreases. The drug is an effervescent tablet packed in a plastic cylinder. Blemaren removes uric acid and dissolves uric acid kidney stones. The daily dosage of the medicine is 4 tablets, the price of which is from 700 to 100 rubles for a package of 80 pieces.

Mixed action drugs include the drug Allomaron, which simultaneously reduces the synthesis of uric acid and increases its excretion from the body. The active substances of the drug are allopurinol and benzobromarone. The daily dose for adults is 1 tablet per day. The average price of a pack of 20 tablets is 280 rubles.

Taking the listed medications in the treatment of gout without consulting a doctor is unacceptable. Incorrect use of drugs for gout and high uric acid can worsen the patient's condition as a result.

Allopurinol: how to take it for gout and what analogues of the drug exist?

Today, the pharmaceutical industry produces many effective medicines for the treatment of articular diseases. Allopurinol for the treatment of gout is one such effective drug.

Gout as a disease of the joints

AT human body metabolism is constantly taking place, in which proteins break down and form energy for life. This process is accompanied by the formation of uric acid, the excretion of which is carried out with the help of the excretory system - the kidneys.

If this function is violated, these salts begin to be deposited in the joints and tissues, leading to the development of gout that affects the joints: hands and fingers, elbows, knees, feet. Gout often occurs in conjunction with arthrosis of the joints. Therefore, when pain in the joints appears, doctors advise to contact specialists for advice.

Signs of gout

Signs of gout cannot be confused with other diseases, they are so specific. Pronounced symptoms of this joint disease are inflammation, acute arthritis with pain syndromes that give relapses. The first symptoms of gout appear in the form of severe pain, starting from the joint of the big toe.

It is the big toe that is affected by gout, becomes the first target, patients complain of:

excruciating severe pain of a sharp nature;
swelling and redness of the skin;
increase in body temperature;
pain in the kidney area and blood in the urine.

The drug Allopurinol

To relieve pain and subsequent treatment of gout, Allopurinol is prescribed - an effective medication used for high levels of uric acid in the blood. The drug is prescribed when laboratory tests show hyperuricemia, with the onset of complications in the form of gout.

Allopurinol is available in the form of tablets in a blister pack of 10 pieces and in a vial of 50 tablets. The cost of the drug varies 70 -100 rubles.

How does Allopurinol work?

Tablets against gout inhibit the formation of uric acid salts and deposition in the tissues. Allopurinol not only reduces the content of uric acid, but also prevents their formation, dissolves and removes salts from the patient's body.

With strict adherence to the instructions of the attending physician, the level of uric acid returns to normal after 5-6 months from the start of taking the medication. Patients notice the relief of severe attacks of the disease after six months, and some after a year. The gout nodules resolve in about this period of taking the medicine.

Indications for use

Allopurinol is characterized by a wide spectrum of action, it is prescribed to patients with hyperuricemia, not amenable to correction with a therapeutic diet.

It has been successfully used for:

urate nephropathy;
therapy of hyperuricemia of a primary or secondary nature;
enzymatic deficiency of congenital origin;
urolithiasis;
the consequences of nephrolithiasis, when stones form in the kidneys;
cytostatic treatment, radiation therapy, as well as corticosteroid therapy;
chronic myeloid leukemia and leukemia.

The drug can be taken for a long time to prevent hyperuricemia. Allopurinol tablets and its analogues are prescribed in combination with other anti-inflammatory and antiseptic drugs.

How to take Allopurinol for gout?

Allopurinol can be taken without chewing with water after meals. The dose is prescribed taking into account the patient's condition, depending on the content of uric acid in the blood.

Dosages and treatment regimens:

For children, the drug is prescribed only in the treatment of malignant neoplasms.. For babies under 6 years old, Allopurinol is prescribed taking into account body weight, 5 mg per kg of weight, for children from 6 to 10 years old, the therapeutic dose is 10 mg, taken, divided by 3-4 times.
Adult patients and children over 10 years of age the daily dose of Allopurinol is determined from 70 to 100 mg, then the dose is evenly increased by 100 mg every 2-3 weeks.
The maintenance dose of Allopurinol is 200-600 mg. depending on the development of the disease. In some severe cases of the disease, a maximum dose of 800 mg is prescribed. With a daily dose of 300 mg, it should be divided into 2-4 doses with the definition of equal intervals between them.
In severe forms of the course of the disease, a single dose of 200 mg is prescribed, the maximum single dose of 300 mg. Treatment with this appointment of Allopurinol continues for 2-4 weeks, then you can switch to a maintenance dose of 100-300 mg.
Elderly people with liver and kidney failure Allopurinol is prescribed with caution and in small doses.

Increasing the dose is carried out under strict careful control of uric acid in the blood. When using the drug, it is recommended to regularly check the condition of the liver.

Contraindications for use

Like any medication, Allopurinol for gout has contraindications for prescribing. Application without taking into account dangerous factors can lead to irreparable consequences.

The drug should not be taken by patients with:

hypersensitivity to the components of the remedy;
serious violations of kidney function;
liver diseases;
reduced creatinine clearance.

Do not drink pills for acute pain, during severe attacks of gout. Do not prescribe Allopurinol to pregnant women and during breastfeeding, as well as to babies under 3 years of age.

The effectiveness of the drug

Before starting therapeutic measures in the treatment of gout, it is recommended to carefully study the mechanism of action of Allopurinol, the presence of contraindications for tablets, and compare these data with the patient's state of health. It is unacceptable to take medication without a doctor's prescription.

With strict adherence to the diet and prescriptions of the urologist, patients begin to notice a relief in their condition after a few months.

Side effects

Usually, taking Allopurinol tablets is normally tolerated by patients, but each organism is individual, in some patients it can cause side effects.

If the patient suffers from insufficiency of kidney and liver function, then taking the medication may cause an adverse reaction.

The use of Allopurinol may be accompanied by:

an increase in blood pressure, bradycardia;
headaches, drowsiness, blurred vision, weakness;
uremia, nephritis and hematuria;
thrombocytopenia, aplastic anemia;
impotence, infertility and gynecomatia;
allergicmanifestations: rash and itching, hyperemia of the skin.

Drug analogues

All analogs are prescribed, like Allopurinol, to reduce uric acid and the formation of its urates in the body of patients with gout. Allopurinol can be replaced with another drug. Only the attending physician can answer the patient's question which drug to choose, since each analogue has its own characteristics and side effects.

Nimesil for gout

Auxiliary treatment

Having identified the problem of the formation of excess uric acid at the onset of the disease, specialists prescribe various auxiliary drugs that reduce the oxidation of the chemical composition of urine and restore normal metabolism.

Among these drugs are blemaren, diprospan and others. In addition to the fact that blemaren alkalizes urine with gout, it helps to reduce the excretion of calcium from the body, reduces the formation of calcium oxalate crystals in the kidneys and joints.

Blemaren is able to dissolve calcium oxalate stones. Blemaren is offered in the pharmacy network in the form of effervescent tablets and granules.

Diprospan affects different kinds metabolism and has an immunosuppressive effect. Diprospan is often prescribed as an anti-inflammatory drug.

Medicines that are used for gout have another purpose. They can act on the problem from different angles.

In this regard, one should not be surprised that the doctor changes appointments. Means for normalizing metabolism, reducing the acidity of urine and reducing inflammation are often prescribed in various combinations.

It is worth noting that the antibiotic for gouty inflammation of the joints is not used. Antibiotics are needed for purulent arthritis.

Until recently, the use of acetylsalicylic acid (aspirin) was considered one of the common methods for removing acidity from urine. This drug has been known since the middle of the 19th century.

Aspirin in modern medicine is not considered the best treatment for gout. You can use aspirin only with the permission of a specialist, otherwise an attack of arthritis may worsen.

In addition, using aspirin, you should pay attention to the condition of the stomach, liver and kidneys. Also, the drug is contraindicated in people prone to bleeding.

Nimesil - Pain reliever for gout

Allopurinol - Means of basic therapy for gout

Nimesil - Pain reliever for gout

Metipred - Anti-inflammatory drug for gout

Arcoxia - Pain reliever for gout

Among the drugs that treat gout are blemaren, diprospan, teraflex, ibuprofen, nimesil, diclofenac, etc. If blemaren can normalize the chemical composition of urine with gout, then diprospan is necessary to normalize metabolism.

Medications such as diclofenac, teraflex, nimesil for arthritis relieve inflammation and have a certain therapeutic effect.

Reducing pain, Teraflex prevents the process of cartilage destruction, stimulating the formation of tissues that protect damaged cartilage. Teraflex is a fairly popular chondroprotector.

It can be taken with extreme caution by people suffering from diabetes. Teraflex is not recommended for bronchial asthma.

In the treatment of gout, the nonsteroidal drug nimesil is used. The remedy primarily relieves pain and fever.

The therapeutic duration of the use of Nimesil can be determined by the doctor. Most often used for 10-14 days until arthritis symptoms subside.

With a prolonged relapse, treatment with nimesil is prolonged. Testimonies of scientists confirm the rather effective treatment of chronic gout with the medicine nimesil.

The best effect is seen when using the drug in granular form.

Diclofenac sodium is an anti-inflammatory nonsteroidal drug. Diclofenac is available in various dosage forms.

It has a strong analgesic and anti-inflammatory effect. Intramuscular injection of diclofenac solution is the most effective method of treatment.

In addition, a specialist may suggest using diclofenac in the form of an ointment, gel, tablets, suppositories. The strength of the drug diclofenac is based on the suppression of an enzyme that regulates pain in the body.

Be sure to pay attention to the fact that all drugs react differently both among themselves and when taken with different foods. For example, diprospan weakens the action of insulin and diuretics.

The action of the drug diprospan can enhance the effect of hormonal drugs. The use of blemaren for gout is contraindicated in patients with infectious processes in the genitourinary tract.

When receiving Blemaren or other medicines as prescribed, it is important to inform the doctor about other medicines taken.

Nutrition for gout

Having received a diagnosis of gout, you should not abuse it, but it is better to completely exclude alcohol from the diet. Drinks containing a certain percentage of alcohol, entering the human body, increase the formation of uric acid.

In the special case where alcohol has to be taken, mitigate the risk by taking absorbent carbohydrates. They are found in crackers, fruits and cheeses.

It is important to remember that not every food is indicated for gouty arthritis. The diet should be discussed with your doctor.

The substance purine increases uric acid. To reduce, if it is difficult to completely eliminate, the intake of this substance, you need to know in which products it is contained.

These are cereals, bread, yeast, meat, fish, asparagus, etc. It is enough to limit the portion of these products for gout to 100 g per 1 dose.

At the beginning of March 2017, I did an ultrasound of the abdominal cavity, which revealed the presence of sand in the kidneys. In the ultrasound protocol, it was recorded: "Calcifications in the right kidney, localization in all groups of calices, single, size up to 3.3 mm. Calcifications in the left kidney, localization in all groups of calyces, several, size up to 3.7 mm. Calcification in the left kidney, localization middle third of the parenchyma, single, size 3 mm. In words, the doctor said that there is a lot of sand in the kidneys, be sure to go to the urologist.

I note right away that a single calcification in the left kidney of 3 mm was found in me back in 2015 and I failed to remove it, although the urologist prescribed the treatment. The uzist explained to me that stones do not come out of this area (the middle third of the parenchyma), so you need to watch him, suddenly he starts to grow. It is quite possible to remove the rest of the calcification.

The urologist first prescribed Urolesan to me, advised me to buy sunflower or rosehip root and drink their decoctions, and then he said, if money allows, buy Blemaren, it is very effective in removing stones from the kidneys.

Front side

And he also explained that the sand can come out, but then form again and so all his life: here and there. Well, let's wait and see. In any case, I will not sit and wait for the stones to grow, I will try to get them out.

Indications for use

At home, the first thing I read was reviews about Blémarin, I didn’t want to throw money away. The reviews were good. And I bought both Blemarin and Urolesan and sunflower root.

back side

Blemaren's packaging is quite voluminous, but it's not surprising, there are so many things!

Package Contents

Tablets of 20 pieces are packaged in tubes. The tablets are large, 2 cm in diameter.

tablets are very large

They dissolve quickly in warm or hot liquids, in cold - you have to wait.

The tablet in hot water hisses very violently

The taste is sweet and sour. If you simply dissolve in water, you can not add sugar, it will not cause soreness. Most often, I threw the pill into the water, but also dissolved it in Essentuki-4 mineral water, in tea with sugar, in carrot juice. The taste of the drink changes, but it has never been nasty. Sometimes she drank the solution through a straw, having read that such acidic drinks negatively affect tooth enamel. Be sure to rinse your mouth after drinking. The instructions didn't say anything about this, but I was playing it safe.

Application scheme

While taking Blemaren, be sure to drink plenty of plain water, at least 1.5 - 2 liters. To promote the release of stones in the urine. Blemaren should be taken 3 times a day after meals. And it is also necessary to follow a certain diet, limit the consumption of meat, it is even better not to eat it at all during the treatment. I literally cried when I read the list of allowed and prohibited foods. I already have to follow a diet, because. I have chronic pancreatitis, cholecystitis and gastritis, but here you can’t eat anything at all, only cucumbers with tea.

Approved Products

I honestly didn’t eat meat for 3 weeks, I cooked myself a lean soup from vegetables, lentils or buckwheat, ground it into a puree. I boiled eggs so that protein food was present. Oatmeal, although not recommended, was still present in my diet, because. I have been eating breakfast for 7 or 8 years oatmeal on the water. In general, she ate what she could, practically without violating the recommended diet, only a couple of times she ate a tiny ring of sausage.

The most interesting part of the treatment is controlling the pH of the urine. The package contains test strips. It is necessary to measure the pH factor 3 times a day with their help. There are a lot of test strips, there are more of them than tablets. But I followed the advice in one of the reviews I read and cut the strips lengthwise into 2 parts so that they last longer. Now that my treatment with Blemaren is ending, I have a lot of test strips left. I will use them to control the pH of the urine and regulate it with the diet. If necessary, you can raise the pH by diluting lemon juice in water and drinking it instead of Blemaren should help. At least the urologist said so.

Test strips and scale

The test strip must be compared with the supplied scale.

A detailed description of how to control the pH factor is in the enclosed booklet "Control Calendar".

Directions for use of blemaren

Before treatment, my pH was 5.8 - 6.5. After the start of treatment, it rose to a maximum of 7.3. But most often it was at the level of 6.9-7.2. Sometimes it dropped to 6.5, it's not clear why. Although it seems to me that there may still be errors in the measurement. If you drink the recommended 2 liters of water per day, urine becomes less concentrated, because you often run to the toilet.

I basically took 1 tablet 3 times a day. Sometimes it turned out that I had to skip the daytime intake, the pH dropped, but in the evening I still dissolved only 1 tablet and in the morning, as a rule, the pH was above 7. After 3 weeks, I began to eat meat, gradually increasing its amount. I can't say that the pH went down drastically. No, it still hovered around the 7 mark. Soups, however, remained lean. So if you do not abuse it, then you can break the diet a little, but not immediately, but after you notice that the stones (sand) began to come out.

Here I also pass to the most important thing. To measure the pH factor, urine should be collected in some kind of container, along the way, observing whether stones come out. I didn’t know what kind of stones were in my kidneys. (They come in several types, and, by the way, the diet for each type of stones is different. With some stones, you can and even need to eat meat.) And in what form they would come out, I also had no idea . I was very afraid of pain when sand passed through the ureter. I didn't have any pain. About 4-5 days after I started taking Blemaren, I noticed that some flakes appeared in the urine. At first they were few, but every day they became more and more. Straight all the urine in flakes, large and small. Didn't know what to think. It doesn’t look like sand and stones, there seemed to be nowhere to catch an infection. And there were no other symptoms indicating an associated illness. I observed this suspension for about 10 days. Then the number of flakes began to decline. I decided to do an ultrasound of the kidneys, especially in the "Control calendar" it is recommended to do an ultrasound at least 1 time in 2 weeks to adjust the therapy. And on the ultrasound, the doctor stated that she did not see any stones measuring 3.3 mm, and even more so 3.7 mm. There is sand, but it is no more than 2 mm in size. And in the examination protocol issued to me, the doctor did not even indicate the presence of this sand, because. there is very little of it. She said that Blemaren should be taken in courses in spring and autumn for prevention. And now everything is within the normal range. Hooray! By the way, the calculus in the left kidney (remember that same 3 mm in the middle third of the parenchyma?) is still in place, Blemaren does not affect it. It doesn't increase, but it doesn't decrease either.

Well, I am satisfied with the result of the treatment. I still take Blemaren, there are a few tablets left. There are practically no flakes in the urine, only sometimes I notice one or two dust particles. For control, I will do an ultrasound somewhere in six months, unless, of course, there is a need to do it earlier. Then I'll post it in the comments.

I also noticed that during menstruation (in the first 2 days) the pH dropped sharply to 5.7-6.3. On the third day, it rose to 6.9, and then higher.

Here is a review. I hope he will help those who doubt whether it is worth spending more than one thousand rubles on Blemaren. (Mine cost me 1055 rubles, but I found the cheapest pharmacy). My answer: it's worth it.

I wish you all good health!

Gout is a complex disease of the joints, which will have to be treated with medications. The articulation is affected due to excessive amounts of uric acid and its salts. The medicine for gout is selected based on the examination of the patient, finding out the causes of the manifestation of the pathology. Treatment must be carried out immediately.

Causes of the appearance and symptoms of pathology

So, gout is most often localized on the big toes. The cause of the development of the disease may be too much physical activity, malnutrition, a violation of metabolic processes in the body.

Gout is an insidious disease. It may not appear for a long time. During the period of exacerbation, it has the following symptoms: swelling of the affected area, an increase in local temperature, severe joint pain, which occurs most often at night. The joint becomes very sensitive to any touch.

Features of the treatment of gout during an exacerbation

So, it is desirable to carry out treatment in a hospital. At this stage of treatment, it is important to eliminate severe pain, eliminate or reduce the intensity of the inflammation process in the joints, and restore normal joint mobility. During the period of exacerbation, the attack is stopped with the help of several groups of drugs.

Non-steroidal anti-inflammatory drugs

Butadion. It is an anti-inflammatory ointment that can relieve pain and high temperature. In addition, this drug is considered a good antirheumatic agent. Apply the ointment in a thin layer around the affected area. There is no need to rub it in.

Indomethacin. This tablet preparation is considered one of the most effective non-steroidal anti-inflammatory drugs. It is prescribed to treat gout on the legs in most cases. The main advantage of the drug is the ability to quickly relieve pain during exacerbation. It is necessary to take tablets three times a day, 0.05 g each. Another form of release of Indomethacin is an ointment.

Ibuprofen. This medicine is also used in the form of tablets. Most often, Ibuprofen is used during the period when the attack has reached its peak, and the symptoms are most pronounced. Daily rate intake can range from 1200 to 2400 mg.

Steroid hormones

These drugs for treatment can not always be taken, as they have a strong effect, but a large number of adverse reactions. If they are appointed, then only in extreme cases, and the period of their application is significantly limited. The most commonly used steroidal anti-inflammatory drugs for treatment are:

Betamethasone. It is an analgesic medicine that is used to reduce inflammation. This hormonal drug can be used systemically or topically.
Methylprednisolone. This anti-inflammatory drug, which is used in the form of ointments, tablets, as well as injections (shots).
Ketazon. It well eliminates the inflammatory process. You can drink it in the form of dragees or tablets. Take the medicine for gout twice a day.

You can take steroid drugs only with the permission of your doctor. Self-use of such funds can be fraught with various health problems.

Colchicine is one of the most effective medicines for gouty feet. This drug is made on a plant basis. It is almost completely safe, so it has no restrictions for patients, except for kidney failure and allergies. Colchicine not only helps relieve severe pain and other symptoms of gout. In addition, the drug stops the formation of uric acid salts. Therefore, this remedy well stops an attack of gout, as it has analgesic properties.

Colchicine helps to remove uric acid from the blood. However, the effectiveness of the drug depends on when the patient starts drinking it. The fact is that Colchicine must be taken on the first day of the onset of inflammation. At the same time, these pills for gout should be drunk every hour (no more than 10 pieces per day).

Colchicine has good reviews from patients who note that with the help of the drug it is possible to achieve a decrease in the level of uric acid in the blood plasma. The medication ends when the intensity of the symptoms decreases, the signs of the disease disappear.

Medicines for the basic therapy of gout

After an acute attack of gout has been stopped, it is necessary to switch to the main treatment, which involves lowering the level of uric acid in the blood, as well as removing salts from the body. The drugs in this case are non-steroidal and practically do not serve to relieve pain or other symptoms of the disease. There are two groups of these drugs:

Uricodepressants (suppress uric acid synthesis)

Allopurinol. It should be taken once a day at a dosage of 300 mg or 3 r / day. 100 mg. It is advisable to take the tablet after a meal. Allopurinol ensures the removal of uric acid from the blood plasma. This remedy prevents complications of the disease. While taking Allopurinol, the patient is required to monitor the level of uric acid in the blood every month. The use of the medicine must be agreed with the doctor. The fact is that Allopurinol can aggravate the condition of the body in the presence of concomitant diseases. The analogue of the presented drug is Thiopurinol.

Uricosuric drugs (remove salts from the joints and purify the blood)

Benemides. These tablets are able to speed up the removal of salts from the body several times. The presented medicine is well tolerated by patients.
Anturan. These tablets are more effective than the previous remedy. However, the drug should not be taken together with Aspirin, which blocks the action of Anturan.
Ampliwix. Treatment with this remedy helps to speed up the removal of uric acid salts from the body. However, it will take from several weeks to a couple of months.
Flexen. The presented medicine is sold in capsules, tablets, ampoules and suppositories. This drug is used if it is necessary to stop an acute attack and other symptoms of gout.

All presented non-steroidal drugs are prescribed by a doctor, depending on the nature of the attack. It is necessary to take into account the age of the patient, the ability of the liver and kidneys to perform their functions well.